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SARMS: Everything You Need To Know About SARMS [2024]

Selective Androgen Receptor Modulators, or SARMs, are popular among athletes and bodybuilders for their potential to enhance performance and muscle growth. However, there are many questions surrounding these compounds. And that’s why we have taken the time in this comprehensive guide, to answer some of the questions and satisfy the worries you may have concerning SARMs; what SARMs are, their safety and legality, and how they’re used.

First things first,

What are SARMs?

SARMS-effect-and-uses-in-Canada

SARMs are a class of therapeutic compounds that bind to androgen receptors in specific tissues like muscle and bone. They have anabolic properties similar to anabolic steroids but with reduced androgenic activity. This means they have the potential to provide benefits for muscle growth and performance enhancement with fewer side effects compared to steroids (Christiansen et al., 2020).

SARMs work by selectively targeting androgen receptors in certain tissues while avoiding others, like the prostate, liver, and skin. This selectivity is what gives them a more favourable safety profile compared to anabolic steroids, which bind to androgen receptors indiscriminately throughout the body (Solomon et al., 2018).

Are SARMs Safe?

While SARMs show promise as a safer alternative to steroids, generally, they are still considered experimental drugs and are not approved for human use by regulatory agencies like the FDA. However, early studies suggest they have a better safety profile than steroids, but their long-term impacts remain unknown (Machek et al., 2020).

Potential side effects of SARMs may include suppression of natural testosterone production, liver toxicity, cardiovascular issues, and changes in cholesterol levels (Solomon et al., 2018). However, the incidence and severity of these side effects appear to be lower than with anabolic steroids.

It’s important to note that much of the safety data on SARMs comes from animal studies or small human trials. Much more research is needed to understand their risks, especially with long-term use fully. Anyone considering using SARMs should be aware of these potential dangers and make an informed decision.

What is Ibutamoren and SARM LGD-4033?

Ibutamoren (MK-677) and Ligandrol (LGD-4033) are two of the most popular and well-researched SARMs.

Ibutamoren is often mislabeled as a SARM, but it’s actually a growth hormone secretagogue. It works by stimulating the pituitary gland to produce more growth hormone and IGF-1. Studies have shown that ibutamoren can increase lean body mass and improve recovery (Svensson et al., 2019).

LGD-4033, on the other hand, is a true SARM that has shown promise for increasing muscle mass and strength. In a clinical trial, LGD-4033 produced dose-dependent increases in lean body mass and improved physical function in healthy young men (Basaria et al., 2013).

Here are some similar SARM products you may consider as well.

Are SARMs Legal in Canada?

The legality of SARMs in Canada is a bit of a gray area. Technically, SARMs are legal to sell, purchase and possess. However, they are illegal to market or sell for human consumption under the Food and Drugs Act. Officially, they can only be sold for research purposes, not as dietary supplements.

This means that while you can legally buy SARMs in Canada, companies cannot make any claims about their effects on the human body or sell them as supplements for bodybuilding or performance enhancement.

SARMs are also prohibited for use by competing athletes under the World Anti-Doping Agency (WADA). If you’re a competitive athlete subject to doping tests, using SARMs could result in disqualification and other penalties. So that’s a grey area for you.

How to Take SARMs

If you’re considering using SARMs, it’s crucial to source them from a reputable company that follows Good Manufacturing Practices (GMP) and provides third-party testing results like Canada Steroids Online. Low-quality or counterfeit SARMs can pose additional health risks.

Dosing and cycle protocols for SARMs are generally based on anecdotal reports rather than clinical data. Typical cycles run from 8-12 weeks, with doses ranging from 10-30mg per day depending on the specific SARM and the user’s goals.

It’s important to start with a low dose and gradually increase it to assess your tolerance and watch for side effects. Never exceed recommended serving sizes or durations.

Post-cycle therapy (PCT) is also recommended after a SARMs cycle to help restore natural testosterone production and maintain gains. Common PCT protocols involve drugs like Clomid or Nolvadex for 4-8 weeks after the cycle.

Is MK-677 a SARM?

MK-677, also known as ibutamoren, is often grouped with SARMs, but it’s actually a growth hormone secretagogue. It works by mimicking the action of ghrelin, a hormone that stimulates the release of growth hormone from the pituitary gland.

While MK-677 is not technically a SARM, it’s often used in conjunction with SARMs or as part of post-cycle therapy due to its potential to increase lean body mass, improve sleep, and aid in recovery (Sigalos & Pastuszak, 2018).

Where to Buy SARMs in Canada

As mentioned earlier, SARMs are legal to sell and purchase in Canada, but only for research purposes. They cannot be marketed or sold as dietary supplements for human consumption. However, this applies as the official market like pharmacies go, you may however purchase from reputable online sources if there’s the need for it.

When looking to buy SARMs in Canada, it’s essential to choose a reputable source that follows GMP standards and provides third-party testing results to ensure purity and potency. Look for companies that are transparent about their manufacturing processes and are willing to answer questions about their products.

Be wary of companies making bold claims about the effects of their products or selling them specifically for bodybuilding or performance enhancement without lab tests to prove so.

Can I Bring SARMs on a Plane?

The legality of travelling with SARMs can be tricky, as laws and regulations vary by country. In Canada, SARMs are legal to possess, so domestic travel should not be an issue.

However, if you’re travelling internationally, there’s a risk that SARMs could be confiscated at the border, even if they’re legal in your destination country. Many countries have strict regulations on the import of drugs and supplements.

To minimize the risk of issues when travelling with SARMs, keep them in their original packaging, bring copies of any prescriptions or receipts, and research the specific laws of your destination country.

However, the safest option is to avoid travelling with SARMs altogether.

Final Take

SARMs offer an enticing promise of anabolic benefits with reduced side effects compared to steroids. However, they remain largely untested and unapproved for human use. While early studies are promising, much more research is needed to fully understand their long-term safety and efficacy.

If you’re considering using SARMs, it’s crucial to be aware of the potential risks and to make an informed decision based on available research. Always source them from reputable suppliers, follow recommended dosing protocols, and be aware of their legal status in your country and any countries you plan to travel to.

As with any experimental drug, the best approach is caution. Hopefully, continued research will provide more definitive answers about the benefits and risks of these compounds. Until then, anyone using SARMs is essentially acting as their own guinea pig. Proceed with care.

 

 


References

Basaria, S., Collins, L., Dillon, E. L., Orwoll, K., Storer, T. W., Miciek, R., Ulloor, J., Zhang, A., Eder, R., Zientek, H., Gordon, G., Kazmi, S., Sheffield-Moore, M., & Bhasin, S. (2013). The safety, pharmacokinetics, and effects of LGD-4033, a novel nonsteroidal oral, selective androgen receptor modulator, in healthy young men. The journals of gerontology. Series A, Biological sciences and medical sciences, 68(1), 87–95. https://doi.org/10.1093/gerona/gls078

Machek, S. B., Cardaci, T. D., Wilburn, D. T., & Willoughby, D. S. (2020). Considerations, Possible Contraindications, and Potential Mechanisms for Deleterious Effect in Recreational and Athletic Use of Selective Androgen Receptor Modulators (SARMs) in lieu of Anabolic Androgenic Steroids: A Narrative Review. Nutrition and metabolic insights, 13, 1178638820945916. https://doi.org/10.1177/1178638820945916

Christiansen, A. R., Lipshultz, L. I., Hotaling, J. M., & Pastuszak, A. W. (2020). Selective androgen receptor modulators: the future of androgen therapy?. Translational andrology and urology, 9(Suppl 2), S135–S148. https://doi.org/10.21037/tau.2019.11.02

Sigalos, J. T., & Pastuszak, A. W. (2018). The Safety and Efficacy of Growth Hormone Secretagogues. Sexual medicine reviews, 6(1), 45–53. https://doi.org/10.1016/j.sxmr.2017.02.004

Solomon, Z. J., Mirabal, J. R., Mazur, D. J., Kohn, T. P., Lipshultz, L. I., & Pastuszak, A. W. (2019). Selective Androgen Receptor Modulators: Current Knowledge and Clinical Applications. Sexual medicine reviews, 7(1), 84–94. https://doi.org/10.1016/j.sxmr.2018.09.006

Svensson, K., Delpachitra, P., Kukreja, S., Changli Ma, R., & Chan, K. M. (2020). Ibutamoren as a Novel Growth Hormone Secretagogue: A Narrative Review. Journal of the Endocrine Society, 4(Suppl 1), MON-606. https://doi.org/10.1210/jendso/bvaa046.1557

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