TB-500 (2mg)


TB-500 stands as a synthetic counterpart to thymosin-beta-4 (TB4), a naturally occurring regenerative peptide present in both animal and human cells. Comprising 43 amino acids, TB4 plays a pivotal role in the intricate process of wound healing. Its influence extends to the orchestration of cellular migration and facilitation of vascular growth, crucial components of tissue repair. Platelets and macrophages release TB4 in response to injury, curbing inflammation, mitigating cellular harm, and diminishing infection risk.

    TB-500’s Functional Impact

    Although TB4 has been extensively studied, TB-500 is regarded as functionally equivalent by researchers and medical practitioners. Thus, the insights gained from investigations into the therapeutic advantages of TB4 are conceptually applicable to TB-500 as well.

    TB4 is renowned for its multifaceted effects, including anti-inflammatory, antifibrotic, and protective properties across the body. By elevating vascular endothelial growth factor (VEGF) and actin levels, it fosters angiogenesis and cellular migration – pivotal processes in the healing journey. Clinicians are particularly intrigued by its potential to repair cardiac and nervous tissues post-ischemic events, illustrating its relevance in cardiac and neurological healing.

    Furthermore, TB4 orchestrates cytokine levels to significantly diminish oxidative stress and curbs fibrosis, thereby enhancing the healing process. These anti-inflammatory attributes equip TB4 to potentially address injuries in organs like the liver, kidneys, heart, and eyes, as well as conditions such as inflammatory bowel disease. The collective impact of TB4 and TB-500 extends beyond injury repair, potentially contributing to the overall integrity of cardiovascular and connective tissues.

    Delivery Routes

    Research exploring TB-500 and TB4 in human and animal models has assessed various administration methods. Primary routes include parenteral, oral, nasal, and topical approaches. When administering injections, subcutaneous and intramuscular methods are preferred. Determining optimal dosages and administration techniques remains dynamic, adapting to specific clinical targets.

    TB-500 Benefits | Clinical Trials and Research

    The present body of knowledge on TB-500 predominantly draws from animal studies, while a limited number of clinical trials have centred on TB4.

    Although further investigation into TB-500’s human application is necessary, current findings highlight a spectrum of therapeutic advantages, notably:

    1. Wound Healing:

    TB4 facilitates healing through diverse physiological mechanisms. By encouraging epithelial and stem cell migration and suppressing apoptosis, TB4’s influence spans various tissue types, including muscles, skin, cardiac, corneal, and nerve cells. Promising clinical trials have shown that topical TB4 application accelerates wound healing in venous ulcers and chronic cutaneous lesions, with indications of reduced scarring and strengthened connective tissues.

    1. Angiogenesis:

    TB4 stimulates the formation of new blood capillaries (angiogenesis), evident in rat models where it upregulates VEGF and enhances endothelial differentiation. This heightened capillary density in ischemic tissue contributes to healing, disease recovery, and cardiovascular health improvement.

    1. Anti-Inflammatory Properties:

    TB4’s anti-inflammatory prowess spans multiple organs, including the liver, kidneys, eyes, heart, and brain. It modulates inflammatory genes and cytokine levels, is observed to reduce inflammatory cells in brain neuroinflammatory disease models and alleviates inflammatory factors in neonates with fetal alcohol disorder. TB4 holds the potential for treating conditions such as renal and liver fibrosis, as well as ulcerative colitis.

    1. Neurological Well-Being:

    TB4 exhibits notable neurological benefits, demonstrating neuroprotective and neurorestorative effects in animal studies following traumatic brain and spinal cord injuries. Its potential extends to conditions like multiple sclerosis and diabetic myopathy, promising advancements in neurological therapeutics.


    These noteworthy findings encompass the significant therapeutic potentials of TB-500 and TB4, though they represent just a subset of their extensive impact. Other potential applications include promoting hair growth and addressing metabolic disorders. Additionally, the global anti-aging potential of TB-500 and TB4 is underscored by their regenerative influence across multiple organs


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