Pramipexole, a potent dopamine agonist, falls within the class of drugs known for their impact on prolactin hormone levels. This compound directly influences prolactin levels by targeting dopamine D3 receptors, exhibiting a stronger binding affinity compared to other dopamine agonists.

Dosage and Cycle Information

Recommended Dosage (Male): Initiate with 0.25mg every other day in the first week, followed by 1mg daily for the entire cycle.

Recommended Dosage (Female): Start with one 0.12mg dose in the first week, then continue with 1mg every 2-3 days for the cycle.

Cycle Length: Variable based on specific steroid regimen, suggested for use with aromatizing steroids.

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    Key Health Benefits 

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    Prevents Progesterone Side Effects

    By blocking progesterone-responsive receptors, Pramipexole can alleviate symptoms associated with progesterone use, such as hot flashes and related symptoms. It has shown effectiveness in reducing anxiety and depression caused by elevated progesterone levels.

    Reduces Sexual Side Effects

    Pramipexole’s action on dopamine receptors can help manage libido and erectile dysfunction. Additionally, it addresses hypogonadism-related symptoms like infertility, low sperm count, and decreased muscle mass.

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    Why Pramipexole is Used in Cycle

    Pramipexole, functioning as a prolactin inhibitor, often complements progesterone-based drugs like Anadrol, Trenbolone Acetate, Trenbolone Enanthate, and Deca Durabolin. This compound is valuable for mitigating the side effects associated with these anabolic steroids, particularly preventing prolactin-induced gynecomastia even with moderate estrogen levels.

    Best Stacks for Pramipexole


    Potential Side Effects

    Pramipexole offers significant anabolic effects, promoting muscle mass and strength. However, it’s essential to consider potential side effects. The most common include insomnia, headaches, nausea, dizziness, constipation, and fatigue. Long-term use may heighten the risk of depression or anxiety.

    It’s crucial for bodybuilders to carefully assess the benefits against potential side effects when considering any supplement, particularly those with the possibility of significant side effects, such as Pramipexole.



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